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OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. Grapefruit juice, an inhibitor of gut mucosal CYP3A, approximately doubles the systemic exposure of oral budesonide. In glucocorticoid receptor affinity studies, the 22R form was twice as co je budesonide active as the 22S epimer. The patient should take the medication as directed and should not exceed the prescribed dosage. Overall, it has lower incidence of systemic manifestations than similar medications.